Events and trends
- 1541 Hernando de Soto is the first European to see the Mississippi River.
- 1542 The first contact of Japan with the West (Portugal).
- 1542 St. John of the Cross is born.
- 1543 The invasion of Ahmad ibn Ibrihim al-Ghazi is finally defeated by a joint Ethiopia-Portuguese force.
- 1547 Miguel de Cervantes (Alcalá de Henares), author of Don Quixote, is born on September 29th in Spain.
- 1549 Francis Xavier is the first Christian Missionary to visit Japan. 
- ^ Roberts, J: "History of the World.". Penguin, 1994.
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