Members of the Appleton family.
- Samuel Appleton (1624/6–1696) ∞ (1) 1651: Hannah Paine; (2) Mary Oliver (1646–1698)
- Isaac Appleton (1664–1747) ∞ Priscilla Baker
- Isaac Appleton (1704–1794) ∞ Elizabeth Sawyer (1709–1785)
- Isaac Appleton (1731–1806) ∞ Mary Adams (1741–1827)
- Samuel Appleton (1766–1853) ∞ 1799: Mary Gore
- Nathan Appleton (1779–1861) ∞ (1) 1806: Maria Theresa Gold; (2) 1839: Harriet Coffin Sumner
- Thomas Gold Appleton (1812–1884)
- Mary "Molly" Appleton (b. 1813) ∞ Robert James Mackintosh (1806-1864)
- Ronald Mackintosh
- Charles Sedgwick Appleton (1815–1835)
- Frances "Fanny" Elizabeth Appleton (1817–1861) ∞ 1843: Henry Wadsworth Longfellow (1807–1882)
- Charles Appleton Longfellow (1844–1893)
- Ernest Wadsworth Longfellow (1845–1921) ∞ 1868: Harriet "Hattie" Spelman
- Fanny Longfellow (1847–1848)
- Alice Mary Longfellow (1850–1928)
- Edith Longfellow (1853–1915) ∞ Richard Henry Dana III (1851–1931)
- Anne Allegra Longfellow (1855–1934)
- George William Appleton (1826–1827)
- William Sumner Appleton (1840–1903) ∞ Edith Stuart (d. 1892)
- William Sumner Appleton Jr. (1874–1947)
- Harriet Sumner Appleton (1841–1923) ∞ Greely S. Curtis (1830–1897)
- Nathan Appleton Jr. (1843–1906)
- Francis Appleton (1733–1819) ∞ Elizabeth Hubbard (1730–1815)
- Rev. Jesse Appleton (1772–1819) ∞ Elizabeth Means (1779–1844)
- Mary Means Appleton (1801–1883) ∞ John Aiken (1797–1867)
- William Appleton Aiken (1833–1929) ∞ Eliza Coit Buckingham (1838–1924)
- Mary Appleton Aiken ∞ Francis H. Snow (1840–1908)
- Frances Appleton (1804–1839) ∞ Alpheus Spring Packard, Sr. (1798–1884)
- William Alfred Packard (1830–1909)
- Alpheus Spring Packard, Jr. (1839–1905)
- Jane Means Appleton (1806–1863) ∞ U.S. President Franklin Pierce (1804–1869)
- Franklin Pierce, Jr. (1836–1836)
- Franklin "Frank" Robert Pierce (1839–1843)
- Benjamin Pierce (1841–1853)
- William Appleton (1808–1830)
- John Appleton (1814–1817)
- Mary Means Appleton (1801–1883) ∞ John Aiken (1797–1867)
- Rev. Jesse Appleton (1772–1819) ∞ Elizabeth Means (1779–1844)
- Rev. Joseph Appleton
- William Appleton (1786–1862) ∞ Mary Ann Cutler (1794-1860)
- William Sullivan Appleton (1815–1836)
- James Amory Appleton (1818–1843) ∞ Mary Ellen Lyman (1819–1875)
- Sarah Elizabeth Appleton (1822–1891) ∞ Amos Adams Lawrence (1814–1886)
- Francis Henry Appleton (1823–1854) ∞ Georgiana Crowninshield Silsbee (1824–1901)
- William Joseph Warren Appleton (1825–1877) ∞ Emily Warren (1818–1905)
- Edward H. Appleton (1827–1827)
- Harriet Cutler Appleton (1828–1857) ∞ Franklin Gordon Dexter (1824–1903)
- Hetty Sullivan Appleton (1831–1901) ∞ Thomas Jefferson Coolidge (1831–1920)
- Charles Hook Appleton (1833–1874) ∞ Isabella Mason (1835–1869)
- William Appleton (1786–1862) ∞ Mary Ann Cutler (1794-1860)
- Samuel Appleton (1738–1819) ∞ Mary White (d. 1834)
- James Appleton (1785–1862) ∞ 1807: Sarah Fuller (1787–1872)
- Samuel Gilman Appleton (1808–1873) ∞ 1829: Sarah Gardiner
- Sarah Fuller Appleton (1811–1884) ∞ 1833: Rev. Stephen Caldwell Millett
- James Appleton (1813–1884) ∞ 1842: Sarah Bristol Edwards
- Mary White Appleton (1815–1905)
- Elizabeth Putnam Appleton (1818–1897) ∞ 1845: Shelton L. Hall
- Joanna Dodge Appleton (1821–1870) ∞ 1843: Peyton R. Morgan
- Hannah Fuller Appleton (1823–1903) ∞ Robert Helyer Thayer (1820–1888)
- Daniel Fuller Appleton (1826–1904) ∞ (1) Julia Randall (d. 1886); ∞ (2) 1889: Susan Cowles
- Francis Randall Appleton (1854–1929)
- Harriette Hooper Appleton (1828–1905) ∞ 1849: Rev. John Cotton Smith
- Anna Whittemore Appleton (1831–) ∞ Dr. Charles H. Osgood
- James Appleton (1785–1862) ∞ 1807: Sarah Fuller (1787–1872)
- Isaac Appleton (1731–1806) ∞ Mary Adams (1741–1827)
- Isaac Appleton (1704–1794) ∞ Elizabeth Sawyer (1709–1785)
- Oliver Appleton (1676–1760) ∞ Sarah Perkins (1677–1770)
- Samuel Appleton (1710–1780) ∞ Mary Russell (1715–1803)
- Daniel Appleton (1750–1828) ∞ Lydia Ela (1747–1826)
- Daniel Appleton (1785–1849) ∞ 1813: Hannah Adams (1791–1859)
- William Henry Appleton (1814–1899) ∞ 1844: Mary Moody Worthen (1824–1884)
- William Worthen Appleton (1845–1924) ∞ Anna Debois Sargent (1845–1908)
- William Henry Appleton (1866–1951)
- Kate Appleton (1848–1873) ∞ 1872: Hobart Seymour Geary (1838–1918)
- Mary Appleton (d. 1934)
- Henry Cozzens Appleton (1863–1925), who married Dora Threlkeld (1847–1927)
- William Worthen Appleton (1845–1924) ∞ Anna Debois Sargent (1845–1908)
- Maria Louisa Appleton (b. 1815) ∞ James E. Cooley (1802–1882)
- John Adams Appleton (1817–1881)
- Charles Horatio Appleton (1819–1820)
- George Swett Appleton (1821–1878) ∞ 1847: Caroline Osgood
- Ellina Appleton (b. 1848) ∞ 1867: William A. Fraser
- Walter Stone Appleton (b. 1849) ∞ Annie P. Beach
- Emma Appleton (b. 1852) ∞ Madan
- George Swett Appleton (1854–1886)
- Francis Appleton (b. 1856)
- Daniel Sidney Appleton (1824–1890) ∞ Melvina W. Marshall (d. 1878)
- Samuel Frances Appleton (1826–1883)
- Sarah Emeline Appleton (1829–1861) who married Leopold Bossange
- William Henry Appleton (1814–1899) ∞ 1844: Mary Moody Worthen (1824–1884)
- Daniel Appleton (1785–1849) ∞ 1813: Hannah Adams (1791–1859)
- Daniel Appleton (1750–1828) ∞ Lydia Ela (1747–1826)
- Samuel Appleton (1710–1780) ∞ Mary Russell (1715–1803)
- Isaac Appleton (1664–1747) ∞ Priscilla Baker
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