Born in 1581

B

• Joseph Bemis (1582-1628)
• Hinneken Buddewis (c1581-?)

C

• Anne Crafford (c1581-1612)
• 
  Robert Cushman (1577-1625)

H

• Jost Heinbach (c1581-)
• Mary Hinckes (1581-1597)
• Christian von Brandenburg-Bayreuth (1581-1655)
• Johanna von Hohenzollern-Hechingen (1581-1634)
• Anne Hopkins (1581-1621)
• 
  Stephen Hopkins (1581-1644)

K

• Jan Knoppert (bef1581-bef1628)

M

• Johan Maas (c1581-?)
• John Masters (1581-1639)
• 
  Samuel Morse (1581-1654)

O

• Thomas Olcott (1581-1627)
• Friedrich von Schleswig-Holstein-Sonderburg-Norburg (1581-1658)
• 
  Massasoit (c1581-1661)

P

• Moses Payne (1581-1643)
• Mary Periam (1581-1681)
• Edward Pynchon of Writtle (1581-)

S

• Jane Sotheron (1581-1675)
• James Stuart, 3rd Earl of Moray (c1581-1638)

V

• Emilia Antwerpiana van Nassau (1581-1657)
• Agathe von Erbach-Erbach (1581-1621)
• Ludwig Günther I. von Schwarzburg-Rudolstadt (1581-1646)
• Katharina von Sternberg (c1581-c1625)

W

• Janet Walker (1581-1656)
• Dorothea von Pfalz-Simmern (1581-1631)