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Claude Lorraine de Guise, Duke of Guise, was born 20 October 1496 in Condé-sur-Moselle, Meurthe-et-Moselle, Lorraine, France to René II de Lorraine (1451-1508) and Filippa van Egmont (1465-1547) and died 12 April 1550 Joinville, Haute-Marne, Champagne-Ardenne, France of unspecified causes. He married Antoinette de Vendôme (1493-1583) 9 June 1513 JL .
Children
| Name | Birth | Death | Joined with |
| Mary of Guise (1515-1560) | 1515 | 1560 | Louis II de Longueville James V of Scotland (1512-1542) |
| Francois de Guise (1519-1563) | 17 February 1519 | 24 February 1563 | Anna d'Este (1531-1607) |
| Louise de Guise (1520-1542) | |||
| Renée de Guise (1522-1602) | |||
| Charles de Chevreuse (1524-1574) | |||
| Claude of Aumale (1526-1573) | |||
| Louis I de Guise (1527-1578) | |||
| Philippe de Guise (1529-1529) | |||
| Pierre (1530-?) | |||
| Antoinette de Guise (1531-1561) | |||
| Francois de Guise (1534-1563) | |||
| René of Elbeuf (1536-1566) | |||
Footnotes (including sources)
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