Daniel Howe was born 5 May 1681 in Marlborough, Middlesex County, Massachusetts to Josiah Howe (1653-1710) and Mary Hanes (1647-1718) and died 22 November 1768 Shrewsbury, Worcester County, Massachusetts of unspecified causes. He married Esther Cloyes (1702-1759) 17 June 1725 in Shrewsbury, Worcester County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Daniel Howe (1728-) | |||
| Nathan Howe (1728-) | |||
| Jotham Howe (1728-1809) | 28 October 1728 Shrewsbury, Worcester County, Massachusetts | February 1809 Barre, Worcester County, Massachusetts | Priscilla Rice (1731-1819) |
| Gideon Howe (1731-1815) | |||
| William Howe (1733-1791) | |||
| Lucy Howe (1736-1802) | |||
| Mary Howe (1738-1817) | |||
Siblings
| Name | Birth | Death | Joined with |
| Mary Howe (1672-1672) | |||
| Mary Howe (1674-) | |||
| Dorothy Howe (1676-) | |||
| Josiah Howe (1678-1766) | 20 September 1678 Marlborough, Middlesex County, Massachusetts | 20 September 1766 Marlborough, Middlesex County, Massachusetts | Sarah Bigelow (1681-1713) |
| Daniel Howe (1681-1768) | 5 May 1681 Marlborough, Middlesex County, Massachusetts | 22 November 1768 Shrewsbury, Worcester County, Massachusetts | Esther Cloyes (1702-1759) |
| Ruth Howe (1684-) | |||