Daniel Pierce, Sr. was born 1 November 1639 in Watertown, Middlesex County, Massachusetts to Anthony Pierce (1611-1678) and Ann Moore (1613-1683) and died 24 March 1723 Watertown, Middlesex County, Massachusetts of unspecified causes. He married Elizabeth Shed (1642-1687) 5 December 1660 in Watertown, Middlesex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Elizabeth Pierce (1665-1737) | |||
| Daniel Pierce (1666-1723) | |||
| John Pierce (1668-1668) | |||
| Ephraim Pierce (1673-1741) | |||
| Josiah Pierce (1675-1747) | 1675 Watertown, Middlesex County, Massachusetts | 1747 Massachusetts | Mary Warren (1675-1732) |
| Joseph Pierce (1677-1747) | |||
| Abigail Pierce (1681-1723) | |||
| Hannah Pierce (1684-) | |||
| Benjamin Pierce (1686-1723) | |||
Siblings
| Name | Birth | Death | Joined with |
| William John Pierce (1633-1705) | |||
| Daniel Pierce (1640-1723) | 1 November 1639 Watertown, Middlesex County, Massachusetts | 24 March 1723 Watertown, Middlesex County, Massachusetts | Elizabeth Shed (1642-1687) |