David Brigham was born 12 April 1678 in Marlborough, Middlesex County, Massachusetts to Thomas Brigham (1641-1717) and Mary Rice (1646-1695) and died 26 June 1750 Westborough, Worcester County, Massachusetts of unspecified causes. He married Deborah Howe (c1670-) 30 September 1708 in Marlborough, Middlesex County, Massachusetts. He married Mary Leonard (1674-1741) 21 October 1709 in Marlborough, Middlesex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| John Brigham (1706-1725) | |||
| David Brigham (1708-1741) | |||
| Name | Birth | Death | Joined with |
| Silas Brigham (1710-1791) | 9 August 1710 Marlborough, Middlesex County, Massachusetts, United States | 11 March 1791 Westborough, Worcester County, Massachusetts, United States | Mindwell Grout (1717-1741) Tabitha Prescott (1710-1801) |
| Jemima Brigham (1712-1777) | |||
| Deborah Brigham (1714-1779) | |||
| Levi Brigham (1716-1787) | 21 August 1716 Marlborough, Middlesex County, Massachusetts | 1 February 1787 Fitzwilliam, Cheshire County, New Hampshire | Susanna Grout (1719-1816) |
| Jonas Brigham (1718-1789) | 25 February 1718 Westborough, Worcester County, Massachusetts, United States | 25 September 1789 Westborough, Worcester County, Massachusetts, United States | Persis Baker (1726-1784) |
| Asa Brigham (1721-1777) | |||
Siblings