Elizabeth Sprague Sampson was born circa 1657 in Plymouth County, Massachusetts to John Sprague (1630-1676) and Ruth Bassett (1632-c1694) and died 27 May 1727 Duxbury, Plymouth County, Massachusetts of unspecified causes. He married Stephen Sampson (1638-1714) 1686 in Duxbury, Plymouth County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Benjamin Sampson (1686-1758) | |||
| John Sampson (1688-1770) | 17 August 1688 Duxbury, Plymouth County, Massachusetts | 26 January 1770 Duxbury, Plymouth County, Massachusetts | Priscilla Bartlett (1696-1758) |
| Hannah Sampson (1690-1753) | |||
| Mary Sampson (1694-) | 1694 Duxbury, Plymouth County, Massachusetts | Massachusetts | Samuel Thayer (1696-1764) |
| Elizabeth Sampson (1696-1762) | |||
| Dorcas Sampson (1698-1754) | |||
Siblings
| Name | Birth | Death | Joined with |
| John Sprague (1656-1728) | 1656 Duxbury, Plymouth County, Massachusetts | 6 March 1728 Lebanon, New London County, Connecticut | Lydia Unknown Sprague (1658-1725) Lois Abel Standish (1677-1731) |
| Elizabeth Sprague (1657-1727) | 1657 Plymouth County, Massachusetts | 27 May 1727 Duxbury, Plymouth County, Massachusetts | Stephen Sampson (1638-1714) |
| Ruth Sprague (1659-1743) | |||
| William Sprague (1664-1712) | 1664 Duxbury, Plymouth County, Massachusetts | 25 November 1712 Atlantic Ocean | Grace Wadsworth (1679-1757) |
| Desire Sprague (1668-) | |||
| Samuel Sprague (1670-1740) | |||
| Dorcus Sprague (1672-) | |||