Elizabeth Whittingham Appleton was born 24 December 1666 in Ipswich, Essex County, Massachusetts to William Whittingham (1640-1672) and Abigail Lawrence (c1642-) and died 30 October 1725 Rowley, Essex County, Massachusetts of unspecified causes. She married Samuel Appleton (1654-1725) 19 June 1682 in Lynn, Essex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Mary Appleton (1683-) | |||
| Hannah Appleton (1684-1766) | 1 November 1684 Lynn, Essex County, Massachusetts, United States | 28 July 1766 Boston, Suffolk County, Massachusetts, United States | William Clarke (1670-) |
| Samuel Appleton (1686-1728) | 21 July 1686 Ipswich, Essex County, Massachusetts | 15 September 1728 London, England | Hannah Gerrish (1700-1736) |
| Elizabeth Appleton (1687-1703) | |||
| Whittingham Appleton (1706-) | |||
| Elizabeth Appleton (1712-1775) | |||
Siblings