Ephraim Peabody Sr was born 1742 in Boxford, Essex County, Massachusetts to Thomas Peabody (1715-1778) and Ruth Cole (1714-1765) and died 3 April 1743 Boxford, Essex County, Massachusetts of unspecified causes. He married Sarah Hutchinson (1750-1816) 1770 in Essex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Sarah Peabody (1771-1834) | |||
| Samuel Peabody (1774-1852) | |||
| Ephraim Peabody (1776-1816) | 17 June 1776 Wilton, Hillsborough County, New Hampshire | 5 July 1816 Wilton, Hillsborough County, New Hampshire | Rhoda Abbott (1784-1853) |
| Elizabeth Peabody (1778-1809) | |||
| John Peabody (1780-1824) | |||
| Lydia Peabody (1782-1811) | |||
| Dorcas Peabody (1784-1809) | |||
| Hannah Peabody (1786-1812) | |||
| Amos Peabody (1788-) | |||
Siblings
| Name | Birth | Death | Joined with |
| Jonathan Peabody (1739-1806) | |||
| Thomas Peabody (1740-1827) | |||
| Samuel Peabody (1741-1760) | |||
| Ephraim Peabody (1742-1803) | 1742 Boxford, Essex County, Massachusetts | 3 April 1743 Boxford, Essex County, Massachusetts | Sarah Hutchinson (1750-1816) |
| Elizabeth Peabody (1744-1821) | 5 January 1744 Boxford, Essex County, Massachusetts, United States | 7 February 1821 Massachusetts, United States | Isaac Sanderson (1738-1814) |
| Ruth Peabody (1746-1818) | |||
| Phinehas Peabody (1750-1835) | |||
| Amos Peabody (1753-) | |||
| Moses Peabody (1755-1842) | |||