Ezekiel Knolton Bigelow was born 4 April 1772 in Westminster, Worcester County, Massachusetts to Jabez Bigelow (1736-1822) and Deborah Knowlton (1734-1816) and died 18 August 1845 Westminster, Worcester County, Massachusetts of unspecified causes. He married Prudence Penniman (1772-1806) 1793 in New Hampshire.
Children
| Name | Birth | Death | Joined with |
| Prudence Bigelow (1796-) | |||
| Sally Bigelow (1797-1813) | |||
| Louisa Bigelow (1801-1843) | |||
| Jabez Bigelow (1803-1885) | September 1803 Springfield, Windsor County, Vermont | 23 July 1885 Quincy, Norfolk County, Massachusetts | Eliza D. Greene (1811-1892) |
| Loring Bigelow (1806-1889) | |||
Siblings
| Name | Birth | Death | Joined with |
| John Bigelow (1762-1829) | |||
| Jabez Bigelow (1764-1851) | |||
| Benjamin Bigelow (1765-1849) | |||
| Deborah Bigelow (1767-1836) | |||
| Abraham Bigelow (1768-1802) | |||
| Susanah Bigelow (1770-1798) | |||
| Ezekiel Knolton Bigelow (1772-1845) | 4 April 1772 Westminster, Worcester County, Massachusetts | 18 August 1845 Westminster, Worcester County, Massachusetts | Prudence Penniman (1772-1806) |
| Luke Bigelow (1774-1860) | |||
| Reuben Bigelow (1775-1834) | |||
| Asa Bigelow (1779-1845) | |||