Francis Appleton was born 25 March 1733 in Ipswich, Essex County, Massachusetts to Isaac Appleton (1704-1794) and Elizabeth Sawyer (1710-1785) and died 29 January 1816 New Ipswich, Hillsborough County, New Hampshire of unspecified causes. He married Elizabeth Hubbard (1730-1815) 17 March 1758 in Ipswich, Essex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Frances Appleton (1759-1849) | |||
| Isaac Appleton (1763-1849) | |||
| Mary Appleton (1764-1820) | |||
| Elizabeth Appleton (1767-1850) | |||
| Jesse Appleton (1772-1819) | 17 October 1772 New Ipswich, Hillsborough, New Hampshire | 12 November 1819 Brunswick, Cumberland County, Maine | Elizabeth Means (1780-1844) |
Siblings
| Name | Birth | Death | Joined with |
| Isaac Appleton (1731-1806) | 30 May 1731 Ipswich, Essex County, Massachusetts | 25 February 1806 New Ipswich, Hillsborough County, New Hampshire | Mary Adams (1741-1827) |
| Francis Appleton (1733-1816) | 25 March 1733 Ipswich, Essex County, Massachusetts | 29 January 1816 New Ipswich, Hillsborough County, New Hampshire | Elizabeth Hubbard (1730-1815) |
| Elizabeth Appleton (1736-1817) | |||
| Samuel Appleton (1738-1819) | 7 August 1738 Ipswich, Essex County, Massachusetts, United States | 15 May 1819 Ipswich, Essex County, Massachusetts, United States | Mary White (1732-1834) |
| Thomas Appleton (1741-1830) | |||
| John Appleton (1742-1829) | |||
| Daniel Appleton (1745-1836) | |||
| William Appleton (1747-1785) | |||
| Mary Appleton (1749-1828) | |||
| Joseph Appleton (1751-1795) | 9 June 1751 Ipswich, Essex County, Massachusetts, United States | 25 July 1795 Brookfield, Worcester County, Massachusetts, United States | Mary Hook (1756-1842) |