Frederick Spencer, 4th Earl Spencer, Earl Spencer, Baron Spencer of Althorp, Viscount Althorp, Viscount Spencer of Althorp, Lord Chamberlain of the Household, was born 14 April 1798 in Whitehall, Greater London, England, United Kingdom to George John Spencer, 2nd Earl Spencer (1758-1834) and Lavinia Bingham (1762-1831) and died 27 December 1857 Althorp, Northamptonshire, England, United Kingdom of unspecified causes. He married Elizabeth Georgina Poyntz (1799-1851) 23 February 1830 in London, England, United Kingdom. He married Adelaide Horatia Elizabeth Seymour (1825-1877) 9 August 1854 in London, England, United Kingdom.
|Georgina Frances Spencer (1832-1852)|
|John Poyntz Spencer, 5th Earl Spencer (1835-1910)||27 October 1835 Spencer House, St James's Place, Greater London, England, United Kingdom||13 August 1910 Althorp, Brington, Northamptonshire, England, United Kingdom||Charlotte Frances Frederica Seymour (1835-1903)|
|Sarah Isabella Spencer (1838-1919)|
|Victoria Alexandrina Spencer (1855-1906)|
|Charles Robert Spencer, 6th Earl Spencer (1857-1922)||30 October 1857 Dallington, Northamptonshire, England, United Kingdom||26 September 1922 London, Greater London, England, United Kingdom||Margaret Baring (1868-1906)|