Henry Stafford, 2nd Duke of Buckingham was born 4 September 1455 to Humphrey Stafford, Earl of Stafford (1424-1458) and Margaret Beaufort (c1427-1474) and died 2 November 1483 of unspecified causes. He married Catherine Woodville (c1458-1497) 1466 JL .
Children
| Name | Birth | Death | Joined with |
| Edward Stafford, 3rd Duke of Buckingham (1478-1521) | 3 February 1478 Brecon, Wales, United Kingdom | 17 May 1521 Tower Hill, London, England, United Kingdom | Eleanor Percy (c1474-1530) |
| Henry Stafford, 1st Earl of Wiltshire (c1479-1523) | 1479 | 6 March 1523 | Cecily Bonville, 7th Baroness Harington (1460-1529) |
| Elizabeth Stafford (c1479-1532) | |||
| Anne Stafford (1483-1544) | 1483 | 1544 Stoke Pogis | George Hastings, 1st Earl of Huntingdon (c1488-1544) |
Footnotes (including sources)
| ‡ General |