Hepzibah Howe Keyes was born 1 October 1706 in Sudbury, Middlesex County, Massachusetts to David Howe (1674-1759) and Hepzibah Dearth (1680-1769) and died 15 April 1792 Shrewsbury, Worcester County, Massachusetts of unspecified causes. She married Cyprian Keyes (1706-1802) 9 April 1723 in Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Hephzibah Keyes (1729-) | |||
| Betty Keyes (1732-1805) | |||
| Zenas Keyes (1733-) | |||
| Cyprian Keyes (1734-1805) | 9 January 1735 Shrewsbury, Worcester County, Massachusetts | 1805 Pittsfield, Berkshire County, Massachusetts | Martha Bush (1735-1822) |
| Levinah Keyes (1736-1756) | |||
| Persis Keyes (1739-1778) | |||
| David Keyes (1741-1745) | |||
Siblings
| Name | Birth | Death | Joined with |
| Thankful Howe (1703-1766) | 15 December 1703 Sudbury, Middlesex County, Massachusetts | 25 January 1766 Hopkington, Middlesex County, Massachusetts | Peter Howe (1696-1766) |
| Hepzibah Howe (1706-1792) | 1 October 1706 Sudbury, Middlesex County, Massachusetts | 15 April 1792 Shrewsbury, Worcester County, Massachusetts | Cyprian Keyes (1706-1802) |
| Eliphalet Howe (1710-1785) | |||
| Israel Howe (1712-1748) | |||
| Ruth Howe (1714-1809) | |||
| David Howe (1717-1802) | |||
| Ezekiel Howe (1720-1796) | |||