Isaac Fortenberry was born circa 1775 in Lancaster County to Isaac Fortenberry (1740-1808) and died circa 1848 Marion County of unspecified causes. He married Cordelia "Bethany" Magee (c1780-aft1846) .
Children
| Name | Birth | Death | Joined with |
| Barbara Fortenberry | |||
| John Wesley Fortenberry | 22 April 1817 MS | 1870 MS | Mary Jane Rebecca Young Faulk |
| William M. Fortenberry, Rev. | 28 December 1799 Lancaster County, South Carolina, United States | 27 October 1867 Marion County, Mississippi, United States | Christian Brown |
| Bilza Delzy Fortenberry | |||
| Martha "Charlotte" Fortenberry | 5 September 1809 | 1 March 1846 "Flowers" Plantation, Marion County | Thomas E. Pigott (1804-1866) |
| Hugh P. Fortenberry | 1811 NC | 1850 Marion County | Obedience "Bedy" Lee |
| Irvin M. Fortenberry | |||