Isaac Gano Sr. was born 1 January 1696 in Staten Island, New York, United States to Stephen Etienne Gano (1654-1697) and Susannah Usselton (1658-1712) and died 21 January 1788 Amwell Township, New Jersey, United States of unspecified causes.
Children
| Name | Birth | Death | Joined with |
| Stephen Gano (1728-1809) | 28 March 1728 Amwell Township, New Jersey, United States | 18 September 1809 Hampshire, West Virginia, United States | Abigail Middleton Allen (1728-1808) |
Siblings
| Name | Birth | Death | Joined with |
| Isaac Gano (1696-1788) | 1 January 1696 Staten Island, New York, United States | 21 January 1788 Amwell Township, New Jersey, United States | Sarah Jane Gulick (1703-1788) |