Isaac Howe was born 8 August 1648 in Sudbury, Middlesex County, Massachusetts to James Howe (1598-1702) and Elizabeth Dane (1607-1693) and died 9 December 1724 Massachusetts of unspecified causes. He married Frances Woods (1645-1718) 17 June 1671 in Marlborough, Middlesex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Elizabeth Howe (1673-1750) | |||
| Sarah Howe (1675-1733) | 28 January 1675 Sudbury, Middlesex County, Massachusetts | 4 December 1733 Marlborough, Middlesex County, Massachusetts | Moses Newton (1669-1736) |
| Mary Howe (1677-1751) | |||
| John Howe (1680-1680) | |||
| John Howe (1682-1754) | |||
| Bethia Howe (1684-1751) | |||
| Hannah Howe (1688-1773) | |||
| Thankful Howe (1691-1741) | |||
Isaac Howe was born 8 August 1648 in Sudbury, Middlesex County, Massachusetts to James Howe (1598-1702) and Elizabeth Dane (1607-1693) and died 9 December 1724 Massachusetts of unspecified causes. He married Frances Woods (1645-1718) 17 June 1671 in Marlborough, Middlesex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Elizabeth Howe (1673-1750) | |||
| Sarah Howe (1675-1733) | 28 January 1675 Sudbury, Middlesex County, Massachusetts | 4 December 1733 Marlborough, Middlesex County, Massachusetts | Moses Newton (1669-1736) |
| Mary Howe (1677-1751) | |||
| John Howe (1680-1680) | |||
| John Howe (1682-1754) | |||
| Bethia Howe (1684-1751) | |||
| Hannah Howe (1688-1773) | |||
| Thankful Howe (1691-1741) | |||
Siblings