Isaac Talley was born 1816 in St. Tammany Parish to John Talley (c1779-1834) and Anna Magee (1790-1857) and died 1886 Washington Parish of unspecified causes. He married Adelaide Ott (1823-1880) 15 August 1839 in St. Tammany Parish.
Children
| Name | Birth | Death | Joined with |
| Samuel James Talley (1841-1911) | 8 January 1841 | 10 November 1911 St. Tammany Parish | Martha E. Joiner (1853-1936) |
| Enoch J. Talley (1847-1922) | 27 October 1847 St. Tammany Parish | 7 April 1922 St. Tammany Parish | Lucy Churchwell Williams (1847-1929) |
| Adelaide Talley (1867-1927) | 29 March 1867 | 7 October 1927 | Alfred L. Jenkins (1861-1934) |