Isabella Hamilton Little was born 23 January 1741 in Albemarle County, Virginia, United States and died 23 September 1821 Franklin County, Georgia, United States of unspecified causes. She married James Little (1737-1807) 1765 in Albemarle County, Virginia.
Children
| Name | Birth | Death | Joined with |
| William Little (1767-) | |||
| David Little (1767-1812) | 11 November 1767 Albemarle County, Virginia, United States | 17 November 1812 Duncan Creek, Laurens County, South Carolina, United States | Charity Adair (1770-1826) |
| James Little (1769-1856) | |||
| Mary Ann Little (1770-) | |||
| John Little (1775-1796) | |||
| Julia Ann Little (1775-1862) | |||
| Ellender Little (1778-1825) | |||
| William Robert Little (1780-1833) | |||
| Nancy Little (1782-1850) | |||
| Walter Little (1785-1845) | |||
Siblings