Israel Holmes was born 1642 in Scituate, Plymouth County, Massachusetts to William Holmes (1592-1678) and Elizabeth Madden (1603-1698) and died 24 February 1683 Plymouth County, Massachusetts of unspecified causes. He married Anna Rouse (1650-c1680) 1677 in Plymouth County, Massachusetts. He married Desire Doty (c1645-1731) 1681 in Plymouth County, Massachusetts.
|Offspring of Israel Holmes and Anna Rouse (1650-c1680)|
|Anna Holmes (1675-)|
|Abigail Holmes (1680-1683)|
|Offspring of Israel Holmes and Desire Doty (c1645-1731)|
|Israel Holmes (c1682-1760)||17 February 1682 Marshfield, Massachusetts Bay Colony||8 September 1760 Marshfield, Massachusetts Bay Colony||Elizabeth Turner (c1682-1754)|
|John Holmes (1684-1754)||15 June 1684 Marshfield, Massachusetts Bay Colony||6 April 1754 Plymouth, Massachusetts Bay Colony||Sarah Thomas (c1687-1761)|