James Withers was born 6 June 1680 in Stafford County, Virginia, United States of America to William Withers (1636-1698) and Mary Littlejohn (c1640-) and died 6 June 1746 Stafford County, Virginia, United States of America of unspecified causes. He married Elizabeth Keene (c1682-1769) 1701 in Stafford County, Virginia, United States.
Children
| Name | Birth | Death | Joined with |
| Anne Withers (1722-1765) | 2 October 1722 Stafford County, Virginia, United States of America | 1765 Virginia, United States of America | Henry Mauzy (c1721-1799) |
Siblings
| Name | Birth | Death | Joined with |
| James Withers (1680-1746) | 6 June 1680 Stafford County, Virginia, United States of America | 6 June 1746 Stafford County, Virginia, United States of America | Elizabeth Keene (c1682-1769) |