John Howe IV was born 16 July 1697 in Marlborough, Middlesex County, Massachusetts to John Howe (1671-1754) and Rebecca Joslin (1672-1731) and died 25 April 1734 Marlborough, Middlesex County, Massachusetts of unspecified causes. He married Thankful Bigelow (1699-1756) 1720 in Marlborough, Middlesex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Cyprian Howe (1726-1790) | 29 March 1726 Marlborough, Middlesex County, Massachusetts | 1790 Marlborough, Middlesex County, Massachusetts | Dorothy Howe (1730-1764) Mary Williams |
| Asa Howe (1728-) | |||
| Anna Howe (1731-) | |||
| Patience Howe (1734-) | |||
Siblings
| Name | Birth | Death | Joined with |
| John Howe (1697-1734) | 16 July 1697 Marlborough, Middlesex County, Massachusetts | 25 April 1734 Marlborough, Middlesex County, Massachusetts | Thankful Bigelow (1699-1756) |
| Sarah Howe (1697-1784) | |||
| Hannah Howe (1706-1757) | 20 November 1706 Marlborough, Middlesex County, Massachusetts, United States | 4 December 1757 Westborough, Worcester County, Massachusetts, United States | Jacob Rice (1707-1788) |
| Ebenezer Howe (1701-1754) | |||
| Rebecca Howe (1702-1744) | 19 March 1702 Marlborough, Middlesex County, Massachusetts, United States | 1744 Massachusetts, United States | John Bigelow (1704-1783) |
| Mary Howe (1704-1724) | |||
| Seth Howe (1708-1789) | |||
| Elizabeth Howe (1710-1784) | |||
| Eunice Howe (1712-1772) | |||
| Dorothy Howe (1715-) | |||