John Sprague was born 5 April 1638 in Hingham, Plymouth County, Massachusetts to William Sprague (1609-1675) and Millicent Eames (1615-1696) and died 26 October 1683 Malden, Middlesex County, Massachusetts of unspecified causes. He married Elizabeth Holbrook (1624-1699) 13 December 1666 in Hingham, Plymouth County, Massachusetts.
John Sprague joined his father-in-law (William Holbrook) and brother in settling Mendon, Massachusetts. In 1675, the town was attacked by Indians and he escaped with his life, joining a crowd of refugees that went to Boston and Charlestown. (NEHGR 129:351)
Children
| Name | Birth | Death | Joined with |
| John Sprague (1669-1669) | |||
| Elizabeth Sprague (1674-1731) | 1674 Rehoboth, Bristol County, Massachusetts | 10 July 1731 Rehoboth, Bristol County, Massachusetts | Benjamin Wilson (1670-1750) |
| John Sprague (1676-) | |||
| Millicent Sprague (1678-) | |||
| William Sprague (1679-1752) | |||
| Persis Sprague (1681-) | |||
| Ebenezer Sprague (1682-1731) | |||
Siblings