Joseph Brigham was born 21 April 1706 in Marlborough, Middlesex County, Massachusetts to Gershom Brigham (1680-1749) and Mehitable Warren (1684-1749) and died 29 July 1786 Marlborough, Middlesex County, Massachusetts of unspecified causes. He married Comfort Bigelow (1707-1755) 26 August 1728 in Marlborough, Middlesex County, Massachusetts. He married Mary Rice (1718-) 3 May 1757 in Marlborough, Middlesex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Mehitabel Brigham (1725-1749) | |||
| Sarah Brigham (1731-) | |||
| Lavina Brigham (1733-1784) | |||
| Joseph Brigham (1735-1742) | |||
| Comfort Brigham (1737-1742) | |||
| Martha Brigham (1739-1769) | 9 September 1739 Marlborough, Middlesex County, Massachusetts | 22 May 1769 Marlborough, Middlesex County, Massachusetts | Daniel Barnes (1736-1813) |
| Stephen Brigham (1741-1764) | |||
| Comfort Brigham (1745-1771) | |||
| Joseph Brigham (1747-1810) | |||
| Jonah Brigham (1747-1827) | |||
| Lucy Brigham (1752-) | |||
Siblings
| Name | Birth | Death | Joined with |
| Martha Brigham (1704-1782) | |||
| Joseph Brigham (1706-1786) | 21 April 1706 Marlborough, Middlesex County, Massachusetts | 29 July 1786 Marlborough, Middlesex County, Massachusetts | Comfort Bigelow (1707-1755) Mary Rice (1718-) |
| Abigail Brigham (1708-1799) | 25 November 1708 Marlborough, Middlesex County, Massachusetts, United States | 6 March 1799 Chesterfield, Cheshire County, New Hampshire, United States | John Snow (1706-1777) |
| Gershom Brigham (1712-1767) | |||
| Benjamin Brigham (1715-1770) | |||