Karl Anton Friedrich Wilhelm von Hohenzollern-Sigmaringen was born 28 January 1922 in Munich, Bavaria, Germany to Franz Joseph von Hohenzollern (1891-1964) and Maria Alix Wettin (1901-1990) and died 3 November 1993 Hechingen, Zollernalp District, Baden-Württemberg, Germany of unspecified causes. He married Alexandra Afif (1919-1996) 15 August 1951 in Rome, Italy.
Siblings
| Name | Birth | Death | Joined with |
| Karl Anton von Hohenzollern (1922-1993) | 28 January 1922 Munich, Bavaria, Germany | 3 November 1993 Hechingen, Zollernalp District, Baden-Württemberg, Germany | Alexandra Afif (1919-1996) |
| Meinrad von Hohenzollern (1925-2009) | 17 January 1925 Sigmaringen, Sigmaringen District, Baden-Württemberg, Germany | 9 September 2009 Murnau am Staffelsee, Garmisch-Partenkirchen District, Bavaria, Germany | Edina von Kap-Herr (1938-) |
| Maria Margarethe von Hohenzollern (1928-2006) | 2 January 1928 Sigmaringen, Sigmaringen District, Baden-Württemberg, Germany | 4 August 2006 Hechingen, Zollernalb District, Baden-Württemberg, Germany | Karl Gregor von Mecklenburg (1933-) |
| Emanuel von Hohenzollern (1929-1999) | 23 February 1929 Munich, Bavaria, Germany | 8 February 1999 Hechingen, Zollernalb District, Baden-Württemberg, Germany | Katharina von Sachsen-Weimar (1943-) |