Knight Sprague was born 12 October 1711 in Plymouth, Plymouth County, Massachusetts to Jeremiah Sprague (1682-1759) and Priscilla Knight (1686-1775) . He married Mary Lewis (1717-1746) 26 May 1735 in Hingham, Plymouth County, Massachusetts. He married Mary Beal (1717-1767) 1747 in Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Knight Sprague (1734-1835) | |||
| Mary Sprague (1736-) | |||
| Sarah Sprague (1738-1831) | |||
| Anthony Sprague (1742-1831) | 29 June 1742 Hingham, Plymouth County, Massachusetts | 20 November 1831 Waltham, Addison County, Vermont, United States | Sarah Harper (1742-1838) |
| Olive Sprague (1744-1745) | |||
| Thomas Sprague (1746-1750) | |||
| Name | Birth | Death | Joined with |
| Asa Sprague (1748-1830) | |||
| James Sprague (1749-1824) | |||
| Caleb Sprague (1755-1828) | |||
| Lucy Sprague (1761-) | |||
Siblings
| Name | Birth | Death | Joined with |
| Jacob Sprague (1709-1785) | |||
| Knight Sprague (1711-) | 12 October 1711 Plymouth, Plymouth County, Massachusetts | Mary Lewis (1717-1746) Mary Beal (1717-1767) | |
| Priscilla Sprague (1712-1798) | |||
| Jeremiah Sprague (1714-1777) | |||
| Susannah Sprague (1716-1790) | |||
| Mary Sprague (1717-1746) | |||
| John Sprague (1719-1801) | |||
| Nehemiah Sprague (1721-) | |||
| Elizabeth Sprague (1723-1785) | |||
| Deborah Sprague (1725-1805) | |||
| Joanna Sprague (1727-1804) | |||