Knowles Godfrey, Sr. was born circa 1735 in Chatham, Barnstable County, Massachusetts, United States to George Godfrey (1707-1768) and Mercy Knowles (1717-1758) and died 19 January 1766 Chatham, Barnstable County, Massachusetts, United States of unspecified causes. He married Jerusha Ryder (1739-1766) 1760 in Essex County, Massachusetts, United States.
Children
| Name | Birth | Death | Joined with |
| Robert Godfrey (1755-1800) | |||
| Knowles Godfrey (1762-1794) | 13 September 1762 Chatham, Barnstable County, Massachusetts | 30 August 1794 Charleston County, South Carolina | Mary Ryder (1766-1822) |
| Mercy Godfrey (1764-1838) | 10 September 1764 Chatham, Barnstable County, Massachusetts, United States | 6 September 1838 Orrington, Penobscot County, Maine, United States | Christopher Taylor (1759-1786) Hezekiah Eldredge (1768-1838) |
Siblings
| Name | Birth | Death | Joined with |
| Martha Godfrey (1734-1816) | |||
| Knowles Godfrey (1735-1766) | 1735 Chatham, Barnstable County, Massachusetts, United States | 19 January 1766 Chatham, Barnstable County, Massachusetts, United States | Jerusha Ryder (1739-1766) |
| Richard Godfrey (1735-1808) | |||
| Benjamin Godfrey (1737-1787) | |||
| Mary Godfrey (1740-1788) | |||
| James Godfrey (1741-) | |||
| Johathan Godfrey (1743-) | |||
| George Godfrey (1745-1769) | |||
| James Godfrey (1747-1779) | |||
| Sarah Godfrey (1750-) | |||
| Molly Godfrey (1753-) | |||
| Jonathan Godfrey (1755-) | |||
Residences
Footnotes (including sources)