Lou Birchie Ayers was born 9 February 1893 in Tippah County, Mississippi, United States to Simpson Green Ayers (1820-1897) and Hattie Hayes (1858-1935) and died 15 February 1946 Sherman, Grayson County, Texas, United States of unspecified causes. She married William Jefferson Blythe (1884-1935) 19 August 1906 in Tippah County, Mississippi, United States.
Children
| Name | Birth | Death | Joined with |
| William Jefferson Blythe (1918-1946) | February 1918 Sherman, Grayson County, Texas, United States | 17 May 1946 Sikeston, Scott County, Missouri, United States | Virginia Adele Gash (1918-1994) Minnie Faye Gash (1923) Wanetta Ellen Alexander (1922) Virginia Dell Cassidy (1923-1994) |
Siblings
| Name | Birth | Death | Joined with |
| Annie D Ayers (-1885) | |||
| William R Ayers (1847-1906) | |||
| Mary Jane Ayres (1848-1929) | |||
| Sarah Elizabeth Ayers (1851-1907) | |||
| Frances C Ayers (1853-1922) | |||
| Martha Loutisha Ayers (1867-1939) | |||
| Name | Birth | Death | Joined with |
| Lege Palmer Ayers (1870-1954) | |||
| Robert Edward Ayers (1872-1928) | |||
| Elijah Palmer Ayers (1873-1954) | |||
| Simpson Green Ayers (1874-1904) | |||
| Thomas Bee Ayers (1877-1967) | |||
| Marshall Richard Ayers (1877-1942) | |||
| Almitche May Ayers (1880-1968) | |||
| Fred G Ayers (1882-1971) | |||
| Nathan Vernie Ayers (1884-1964) | |||
| Minnie B Ayers (1887-1939) | |||
| Lou Birchie Ayers (1891-1946) | 9 February 1893 Tippah County, Mississippi, United States | 15 February 1946 Sherman, Grayson County, Texas, United States | William Jefferson Blythe (1884-1935) |
| Lona M Ayers (1896-1969) | |||