Lydia Pierce Upham was born 18 March 1745 in Concord, Middlesex County, Massachusetts to Nathan Pierce (1716-1793) and Lydia Martin (1718-1798) and died 11 December 1822 Sturbridge, Worcester County, Massachusetts of unspecified causes. She married Asa Upham (1736-1826) 10 December 1761 in Worcester County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Lydia Upham (1762-) | |||
| Joseph Upham (1764-1857) | |||
| Abigail Upham (1766-1887) | |||
| Mary Upham (1767-1820) | 27 October 1767 Sturbridge, Worcester County, Massachusetts | 2 June 1820 Pawlet, Rutland County, Vermont | Ephraim Robinson (1760-1843) |
| Eunice Upham (1769-1836) | |||
| Asa Upham (1771-1858) | |||
| Rachel Upham (1773-1794) | |||
| Lois Upham (1775-) | |||
| Ezekiel Upham (1778-1804) | |||
| Hannah Upham (1780-1859) | |||
| Thankful Upham (1783-1842) | |||
| Samuel Upham (1787-1850) | |||
Siblings
| Name | Birth | Death | Joined with |
| Joseph Pierce (1737-1793) | |||
| David Pierce (1739-) | |||
| Freelove Pierce (1742-1809) | |||
| Nathan Pierce (1744-1776) | |||
| Lydia Pierce (1745-1822) | 18 March 1745 Concord, Middlesex County, Massachusetts | 11 December 1822 Sturbridge, Worcester County, Massachusetts | Asa Upham (1736-1826) |
| Benjamin Pierce (1747-1796) | |||
| Pardon Pierce (1748-1796) | |||
| Mary Pierce (1750-1827) | |||
| Marten Pierce (1752-1844) | |||
| Martha Pierce (1752-) | |||
| Judith Pierce (1753-1806) | |||
| Hezekiah Pierce (1755-1800) | |||
| Pegleg Pierce (1756-1828) | |||
| Preserved Pierce (1758-1828) | 28 July 1758 Rehoboth, Bristol County, Massachusetts | 29 June 1828 Swansea, Massachusetts | Sarah Lewis (1761-1823) Nancy Cushing (1762-) |
| Isaac Pierce (1763-1849) | 22 September 1763 Rehoboth, Bristol County, Massachusetts, United States | 26 November 1849 Rehoboth, Bristol County, Massachusetts, United States | Anna Fitch (1763-1809) Mary Bowen (1779-1838) Elizabeth Carpenter (1767-) |
| Chloe Pierce (1765-) | |||