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Manuel II Palaiologos, Byzantine Emperor, was born 27 June 1350 to John V Palaiologos (1332-1391) and Helena Kantakouzene (1333-1396) and died 21 July 1425 of unspecified causes. He married Jelena Dragaš (c1372-1450) 10 February 1392 JL .
Children
| Name | Birth | Death | Joined with |
| Daughter I Palaiologina (?-?) | |||
| Constantine Palaiologos (?-?) | |||
| John VIII Palaiologos (1392-1448) | 18 December 1392 | 31 October 1448 | Anna of Moscow (1393-1417) Sophia of Montferrat (?-1434) Maria of Trebizond (?-1439) |
| Andronikos Palaiologos (?-1429) | |||
| Daughter II Palaiologina (?-?) | |||
| Theodore II Palaiologos (?-1448) | |||
| Michael Palaiologos (?-?) | |||
| Constantine XI Palaiologos (1405-1453) | 8 February 1405 | 29 May 1453 | Theodora Tocco (?-1429) Caterina Gattilusio (?-1442) |
| Demetrios Palaiologos (c1407-1470) | |||
| Thomas Palaiologos (c1409-1465) | 1409 | 12 May 1465 | Katharina Zaccaria of Achaea (1411-1462) |
| Name | Birth | Death | Joined with |
| Isabella Palaiologina (?-?) | |||
Residences