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Manuel I de Aviz de Portugal, King of Portugal, King of the Algarves, was born 31 May 1469 to Fernando, Duke of Viseu (1433-1470) and Beatriz of Portugal (1430-1506) and died 13 December 1521 of unspecified causes. He married Isabella of Asturias (1470-1498) October 1497 JL . He married Maria of Aragon (1482-1517) 30 October 1500 JL . He married Eleonore of Castile (1498-1558) 16 July 1518 JL .
Children
| Name | Birth | Death | Joined with |
| Miguel da Paz, Prince of Asturias (1498-1500) | |||
| Name | Birth | Death | Joined with |
| John III of Portugal (1502-1557) | 7 June 1502 Lisbon | 11 June 1557 Lisbon | Katharina of Castile (1507-1578) Isabel Moniz |
| Isabella of Portugal (1503-1539) | 24 October 1503 Lisbon, Portugal | 1 May 1539 Toledo, Spain | Charles V of the Holy Roman Empire (1500-1558) |
| Beatriz of Portugal (1504-1538) | 31 December 1504 Lisbon | 1 August 1538 Nice | Charles III de Savoie (1486-1553) |
| Luís of Portugal (1506-1555) | |||
| Fernando of Guarda and Trancoso (1507-1534) | |||
| Afonso of Portugal (1509-1540) | |||
| Maria of Portugal (1513-1513) | |||
| Henry I of Portugal (1512-1580) | 31 January 1512 | 31 January 1580 | |
| Duarte of Guimarães (1515-1540) | 7 October 1515 Lisbon | 20 September 1540 Lisbon | Isabella of Braganza (1514-1576) |
| António of Portugal (1516-1516) | |||
| Name | Birth | Death | Joined with |
| Carlos of Portugal (1520-1521) | |||
| Maria of Portugal (1521-1577) | |||