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Maria Isabella Leopoldina Amélia di Borbone delle Due Sicilie was born 22 July 1846 in Naples, Metropolitan City of Naples, Campania, Italy to Luigi di Borbone delle Due Sicilie (1824-1897) and Januária do Brasil (1822-1901) and died 14 February 1859 Naples, Campania, Italy of unspecified causes.
Siblings
| Name | Birth | Death | Joined with |
| Luigi di Borbone delle Due Sicilie (1845-1909) | 18 July 1845 Naples, Campania, Italy | 27 November 1909 Nice, Alpes-Maritimes, Provence-Alpes-Côte d'Azur, France | Amelia Bellow-Hamel y Penot (1847-1914) |
| Maria Isabella di Borbone delle Due Sicilie (1846-1959) | 22 July 1846 Naples, Metropolitan City of Naples, Campania, Italy | 14 February 1859 Naples, Campania, Italy | |
| Filippo di Borbone delle Due Sicilie (1847-1922) | 12 August 1847 Naples, Campania, Italy | 9 July 1822 Paris, France | Flora Boonen (1847-1912) |
| Germana di Borbone delle Due Sicilie (1848-1848) | 1848 Naples, Campania, Italy | 1848 Naples, Campania, Italy | |
| Emanuele di Borbone delle Due Sicilie (1851-1851) | 24 January 1851 Naples, Metropolitan City of Naples, Campania, Italy | 25 January 1851 Naples, Campania, Italy | |