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Maria of Aragon was born 29 June 1482 to Ferdinand II of Aragon (1452-1516) and Isabella I of Castile (1451-1504) and died 7 March 1517 of unspecified causes. She married Manuel I of Portugal (1469-1521) 30 October 1500 JL .
Children
| Name | Birth | Death | Joined with |
| John III of Portugal (1502-1557) | 7 June 1502 Lisbon | 11 June 1557 Lisbon | Katharina of Castile (1507-1578) Isabel Moniz |
| Isabella of Portugal (1503-1539) | 24 October 1503 Lisbon, Portugal | 1 May 1539 Toledo, Spain | Charles V of the Holy Roman Empire (1500-1558) |
| Beatriz of Portugal (1504-1538) | 31 December 1504 Lisbon | 1 August 1538 Nice | Charles III de Savoie (1486-1553) |
| Luís of Portugal (1506-1555) | |||
| Fernando of Guarda and Trancoso (1507-1534) | |||
| Afonso of Portugal (1509-1540) | |||
| Maria of Portugal (1513-1513) | |||
| Henry I of Portugal (1512-1580) | 31 January 1512 | 31 January 1580 | |
| Duarte of Guimarães (1515-1540) | 7 October 1515 Lisbon | 20 September 1540 Lisbon | Isabella of Braganza (1514-1576) |
| António of Portugal (1516-1516) | |||