Mark Mothersbaugh was born 18 May 1950 in Akron, Ohio, United States to Robert Leroy Mothersbaugh (1925-2016) and Mary Margaret Ratzer (1924-2014) .
Children
| Name | Birth | Death | Joined with |
| Hope Mothersbaugh (2001) | 16 August 2001 Los Angeles, California, United States | ||
| Margaret Mothersbaugh (2004) | 18 July 2004 Wenling, China | ||
Siblings
| Name | Birth | Death | Joined with |
| Mark Allen Mothersbaugh (1950) | 18 May 1950 Akron, Ohio, United States | Anita Greenspan (1964) | |
| Robert Leroy Mothersbaugh (1952) | |||
| James Michael Mothersbaugh (1954) | |||
| Susan Marie Mothersbaugh (1955) | 19 September 1955 Akron, Ohio, United States | Joseph Anthony Hite (1955) | |
| Amy Marie Mothersbaugh (1962) | |||