Mary Adams Appleton was born 14 March 1741 in Concord, Middlesex County, Massachusetts to Joseph Adams (1702-1790) and Precilla Russell (1705-1765) and died 22 May 1827 Hillsborough, Hillsborough County, New Hampshire of unspecified causes. She married Isaac Appleton (1731-1806) 24 April 1760 in Concord, Middlesex County, Massachusetts.
Children
| Offspring of Isaac Appleton III and Mary Adams (1741-1827) | |||
| Name | Birth | Death | Joined with |
| Isaac Appleton (1762-1853) | |||
| Joseph Appleton (1764-1791) | |||
| Samuel Appleton (1766-1853) | 22 June 1766 New Ipswich, Hillsborough County, New Hampshire | 12 July 1853 Boston, Suffolk County, Massachusetts | Mary Lekain (1788-1870) |
| Aaron Appleton 91768-1852) | |||
| Dolly Appleton (1770-1859) | |||
| Moses Appleton (1773-1849) | |||
| Mary Appleton (1775-1853) | |||
| Ebenezer Appleton (1777-1780) | |||
| Nathan Appleton (1779-1861) | 6 October 1779 New Ipswich, Hillsborough County, New Hampshire | 14 July 1861 Boston, Suffolk County, Massachusetts | Maria Theresa Gold (1786-1833) Maria Theresa Gold (1786-1833) Harriet Coffin Sumner (1802-1867) |
| Emily Appleton (1781-1809) | |||
| Ebenezer Appleton (1784-1833) | 7 June 1784 New Ipswich, Hillsborough, New Hampshire | 29 April 1833 Cambridge, Middlesex County, Massachusetts | Sarah Patterson (1788-1837) |
| Emma Appleton (1787-1791) | |||
