Mary Lewis Sprague was born 6 September 1717 in Massachusetts to Joseph Lewis (1676-1767) and Sarah Marsh (1681-1717) and died 3 September 1746 of unspecified causes. She married Knight Sprague (1711-) 26 May 1735 in Hingham, Plymouth County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Knight Sprague (1734-1835) | |||
| Mary Sprague (1736-) | |||
| Sarah Sprague (1738-1831) | |||
| Anthony Sprague (1742-1831) | 29 June 1742 Hingham, Plymouth County, Massachusetts | 20 November 1831 Waltham, Addison County, Vermont, United States | Sarah Harper (1742-1838) |
| Olive Sprague (1744-1745) | |||
| Thomas Sprague (1746-1750) | |||
Siblings