Mary Rice Brigham was born 8 April 1767 in Marlborough, Middlesex County, Massachusetts to Benjamin Rice (1740-1811) and Susanna Weeks (1743-1826) and died 15 June 1797 of unspecified causes. She married Lewis Brigham (1756-1803) 18 September 1786 in Marlborough, Middlesex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Asa Brigham (1788-1844) | 31 August 1788 Marlborough, Middlesex County, Massachusetts, United States | 3 August 1844 Washington County, Texas, United States | Elizabeth Swift Babcock (1790-1833) Ann Johnson Mathers (c1790-) |
| Susanna Brigham (1790-) | |||
| Sally Brigham (1792-) | |||
| Mary Brigham (1794-) | |||
| Abigail Brigham (1796-) | |||
Siblings
| Name | Birth | Death | Joined with |
| Elizabeth Rice (1765-1838) | |||
| Mary Rice (1767-1797) | 8 April 1767 Marlborough, Middlesex County, Massachusetts | 15 June 1797 | Lewis Brigham (1756-1803) |
| Phebe Rice (1768-1794) | |||
| Stephen Rice (1771-1788) | |||
| Susanna Rice (1771-) | |||
| Benjamin Rice (1774-1833) | |||
| John Rice (1780-1788) | |||