Nancy Barker Grigsby was born circa 1780 in Virginia to Aaron Hamilton Barker (1766-1823) and Permely Ash (1772-) and died 15 September 1848 Spencer County, Indiana of unspecified causes. She married Reuben Davis Grigsby (1774-1855) 30 March 1801 in Nelson County, Kentucky.
Children
| Name | Birth | Death | Joined with |
| Aaron Grigsby (1801-1832) | 1801 Gentryville, Spencer County, Indiana | 1832 Gentryville, Spencer County, Indiana | Sarah Lincoln (1807-1828) |
| Charles Grigsby (1803-1885) | |||
| John Grigsby (1804-) | |||
| William Grigsby (1805-1871) | |||
| Aaron Grigsby (1807-1831) | |||
| Reuben Grigsby (1807-1870) | |||
| Permely Nancy Grigsby (1809-) | |||
| Nathaniel Grigsby (1811-1890) | 11 October 1811 Nelson County, Kentucky | 16 April 1890 Attica, Harper County, Kansas | Mahulda Cummins (1817-1853) Catherine Davis (1826-1897) |
| James Grigsby (1813-1889) | |||
| Redmond D Grigsby (1818-1907) | |||
| Mildred Grigsby (1820-) | |||
| Elizabeth Grigsby (1820-1889) | |||
| Lydia Grigsby (1820-1884) | |||
| Mary Grigsby (1825-) | |||
Siblings