Nathaniel Lewis was born 22 October 1740 in Guilford, New Haven County, Connecticut to Gersham Lewis (1704-1766) and Mary Maltby (1708-1793) and died 1817 Blockville, Chautauqua County, New York of unspecified causes. He married Esther Tuttle (1747-1824) 16 January 1676 in New Haven County, Connecticut.
Children
| Name | Birth | Death | Joined with |
| Elizabeth Lewis (1767-1842) | 19 November 1767 Goshen, Litchfield County, Connecticut | 16 February 1842 Harmony, Susquehanna County, Pennsylvania | Isaac Hale (1763-1839) |
| Nathaniel Lewis (1769-1860) | |||
| Enos Lewis (1772-1860) | |||
| Esther Lewis (1774-1842) | |||
| Jehial Lewis (1776-) | |||
| John Lewis (1777-1860) | |||
| Molly Lewis (1779-) | |||
| Mary Lewis (1779-1850) | |||
| Reuben Lewis (1782-1830) | |||
| Miles Lewis (1783-1820) | |||
| Amos Lewis (1785-1876) | |||
| Caroline Lewis (1795-1838) | |||
Siblings
| Name | Birth | Death | Joined with |
| John Lewis (1736-1758) | |||
| Gershom Lewis (1738-1739) | |||
| Nathaniel Lewis (1740-1817) | 22 October 1740 Guilford, New Haven County, Connecticut | 1817 Blockville, Chautauqua County, New York | Esther Tuttle (1747-1824) |
| Mary Lewis (1742-1823) | |||
| Elizabeth Lewis (1743-1820) | |||
| Osias Lewis (1750-1812) | |||
| Reuben Lewis (1753-1779) | |||