Biography
Penelope Wriothesley was born 8 November 1598 in Tichfield, Hampshire, England, United Kingdom to Henry Wriothesley, 3rd Earl of Southampton (1573-1624) and Elizabeth Vernon (1573-aft1655) and died 16 July 1667 of unspecified causes. She married William Spencer (c1591-1636) 1614 .
Children
| Name | Birth | Death | Joined with |
| Elizabeth Spencer (1618-1672) | |||
| Henry Spencer, 1st Earl of Sunderland (1620-1643) | 1620 | 20 September 1643 Newbury, Berkshire, England, United Kingdom | Dorothy Sidney (1617-1684) |
| Mary Spencer (1621-1622) | |||
| Anne Spencer (1623-) | |||
| Catherine Spencer (1624-) | |||
| Alice Spencer (1625-1675) | |||
| Margaret Spencer (1627-1693) | 1627 | 20 January 1693 London, Greater London, England, United Kingdom | Anthony Ashley-Cooper, 1st Earl of Shaftesbury (1621-1683) |
| Robert Spencer, 1st Viscount Teviot (1628-1694) | |||
| William Spencer (1630-1687) | |||
| Richard Spencer (1631-1653) | |||
| Thomas Spencer (1633-) | |||
| John Spencer (1635-) | |||
| Rachel Spencer (1637-bef1638) | |||