Persis Baker Brigham was born 8 November 1726 in Westborough, Worcester County, Massachusetts to Edward Baker (1696-) and Persis Brigham (1703-) and died 3 November 1784 Westborough, Worcester County, Massachusetts of unspecified causes. She married Jonas Brigham (1718-1789) 16 January 1746 in Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Martha Brigham (1746-) | |||
| Hannah Brigham (1749-) | |||
| Jonas Brigham (1748-1826) | 29 October 1748 Worcester, Worcester County, Massachusetts | 1 December 1826 Bakersfield, Franklin County, Vermont | Annah Draper (1749-1802) |
| Antepas Brigham (1750-1756) | |||
| Eli Brigham (1752-1753) | |||
| Edward Brigham (1754-) | |||
| Barnabas Brigham (1756-1817) | |||
| Antipas Brigham (1758-1840) | |||
| Daniel Brigham (1759-1837) | |||
| Baby Brigham (1761-) | |||
| David Brigham (1762-1851) | |||
| Persis Brigham (1763-1775) | |||
| Joseph Brigham (1766-1827) | |||
| William Brigham (1768-1779) | |||
Siblings
| Name | Birth | Death | Joined with |
| Samuel Baker (1722-1798) | |||
| Solomon Baker (1725-1777) | |||
| Persis Baker (1726-1784) | 8 November 1726 Westborough, Worcester County, Massachusetts | 3 November 1784 Westborough, Worcester County, Massachusetts | Jonas Brigham (1718-1789) |
| Abigail Baker (1728-1776) | |||
| Hephzibath Baker (1729-) | |||
| Elizabeth Baker (1734-) | |||
| Joseph Baker (1736-1800) | |||
| Leveniah Baker (1738-) | |||
| Ezra Baker (1740-) | |||
| Mary Baker (1746-) | |||