Piero I de' Medici, Signore di fatto di Firenze, was born 1416 in Florence, Italy to Cosimo de' Medici (1389-1464) and Contessina de' Bardi (c1390-1473) and died 2 December 1469 Florence, Italy of unspecified causes. He married Lucrezia Tornabuoni (1425-1482) 3 June 1444 JL .
|Offspring of Piero I de' Medici and Lucrezia Tornabuoni (1425-1482)|
|Lorenzo de' Medici (1449-1492)||1 January 1449 Florence, Republic of Florence, Italy||9 April 1492 Florence, Republic of Florence, Italy||Clarice Orsini (c1453-1488)|
|Maria de' Medici (1445-1470)|
|Bianca de' Medici (1446-1488)|
|Lucrezia de' Medici (1450-1493)|
|Giuliano I de' Medici (1453-1478)||1453||26 April 1478 Florence, Italy||Fioretta Gorini (c1458)|