Ruth Cooke Holmes was born 4 February 1721 in Plympton, Plymouth County, Massachusetts, United States to Francis Cooke (1696-1724) and Ruth Sylvester (1702-1779) and died 23 May 1790 Kingston, Plymouth County, Massachusetts, United States of unspecified causes. She married Josiah Holmes (1716-1782) 29 March 1740 in Kingston, Plymouth County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Simeon Holmes (1741-1812) | 27 February 1741 Pembroke, Plymouth County, Massachusetts, United States | 30 October 1812 Carver, Plymouth County, Massachusetts, United States | Mercy Weston (1741-1822) |
| Francis Holmes (1743-1812) | |||
| Josiah Holmes (1745-1811) | |||
| Ruth Holmes (1748-1790) | |||
| Jonathan Holmes (1748-1808) | |||
| Susannah Holmes (1750-1803) | |||
| Gershom Holmes (1752-) | |||
| John Holmes (1754-1810) | |||
| Silvester Holmes (1756-1810) | |||
| Eleazer Holmes (1756-1760) | |||
| Grace Holmes (1760-1760) | |||
| Eleazer Holmes (1762-1762) | |||
| Elizabeth Holmes (1764-1812) | |||
Siblings
| Name | Birth | Death | Joined with |
| Ruth Cooke (1721-1790) | 4 February 1721 Plympton, Plymouth County, Massachusetts, United States | 23 May 1790 Kingston, Plymouth County, Massachusetts, United States | Josiah Holmes (1716-1782) |
| Susannah Cooke (1723-1766) | |||