Samuel Appleton was born 22 January 1713 in Ipswich, Essex County, Massachusetts to Oliver Appleton (1677-1759) and Sarah Perkins (1684-1769) and died 27 October 1780 Haverhill, Essex County, Massachusetts of unspecified causes. He married Mary Russell (1716-1803) 12 October 1736 in Andover, Essex County, Massachusetts.
Children
| Name | Birth | Death | Joined with |
| Samuel Appleton (1740-1784) | |||
| Thomas Appleton (1743-1803) | |||
| Mary Appleton (1746-1830) | |||
| Hannah Appleton (1748-1750) | |||
| Daniel Appleton (1751-1828) | 16 March 1751 Haverhill, Essex County, Massachusetts | 15 May 1828 Haverhill, Essex County, Massachusetts | Lydia Ela (1747-1826) |
| William Appleton (1754-1798) | |||
| Hannah Appleton (1756-1824) | |||
Siblings
| Name | Birth | Death | Joined with |
| Oliver Appleton (1702-1787) | |||
| William Appleton (1703-1725) | |||
| John Appleton (1705-1794) | |||
| Joseph Appleton (1705-1782) | |||
| Sarah Appleton (1709-1798) | |||
| Samuel Appleton (1713-1780) | 22 January 1713 Ipswich, Essex County, Massachusetts | 27 October 1780 Haverhill, Essex County, Massachusetts | Mary Russell (1716-1803) |
| Thomas Appleton (1714-1724) | |||
| Lucy Appleton (1717-1737) | |||
| Daniel Appleton (1720-1807) | |||
| Nathaniel Appleton (1721-1789) | |||
| Priscilla Appleton (1724-1725) | |||