Samuel Blair Smith was born 10 July 1784 to John Blair Smith (1756-1799) and Elizabeth Fisher Nash (1758-1843) and died 28 November 1834 of unspecified causes. He married Margaret Ferguson (1787-1861) 22 May 1806 .
Children
| Name | Birth | Death | Joined with |
| Charles Ferguson Smith (1807-1862) | |||
| Francis Nash Sharpe Smith (1809-1810) | |||
| Elizabeth Ferguson Smith (-1842) | |||
| Ann Hill Smith (1816-1892) | |||