Samuel Cotton was born 21 February 1676 in Concord, Massachusetts, United States to John Scott Cotton (1643-1684) and Mary Stowe (1643-1727) and died 9 March 1760 Middletown, Connecticut, United States of unspecified causes.
Children
| Name | Birth | Death | Joined with |
| William Cotton (1720-1788) | 18 September 1720 Middletown, Connecticut, United States | 9 June 1788 Fairfax, Virginia, United States | Mary Taylor (1723-1788) |
Siblings
| Name | Birth | Death | Joined with |
| Samuel Cotton (1676-1760) | 21 February 1676 Concord, Massachusetts, United States | 9 March 1760 Middletown, Connecticut, United States | Experience Hall (1683-1762) |