Samuel Drew was born 21 February 1678 in Plympton, Plymouth County, Massachusetts to John Drew (1642-1721) and Hannah Churchill (1649-1721) and died 21 May 1739 Kingston, Plymouth County, Massachusetts of unspecified causes. He married Ruth Delano (1683-1767) 1722 in Plymouth County, Massachusetts.
Siblings
| Name | Birth | Death | Joined with |
| Elizabeth Drew (1673-1733) | 5 February 1673 Plymouth, Plymouth County, Massachusetts | 5 February 1673 Plymouth, Plymouth County, Massachusetts | Benoni Delano (1667-1738) |
| John Drew (1676-1745) | 29 August 1676 Plymouth County, Massachusetts | 10 July 1745 Halifax, Plymouth County, Massachusetts | Sarah Delano (1682-1746) |
| Samuel Drew (1678-1739) | |||
| Mary Drew (1679-) | |||
| Thomas Drew (1681-1745) | |||
| Nicholas Drew (1684-1735) | |||
| Lemuel Drew (1687-1738) | |||