Samuel Griffin was born 16 July 1638 in Washington, Virginia, United States to Thomas George Griffin (1598-1651) and Beatrix Joan Northrop (1600-1661) and died 5 September 1703 Heathsville, Virginia, United States of unspecified causes.
Children
| Name | Birth | Death | Joined with |
| Martin Griffin (1666-1718) | 13 June 1666 Windsor, North Carolina, United States | 1 June 1718 Windsor, North Carolina, United States | Elizabeth Smithwick (1669-1751) |
Siblings
| Name | Birth | Death | Joined with |
| Samuel Griffin (1638-1703) | 16 July 1638 Washington, Virginia, United States | 5 September 1703 Heathsville, Virginia, United States | Sarah Clare (1640-1675) |