Samuel Lathrop, IV was born 1 January 1721 in Norwich, New London County, Connecticut, United States to Samuel Lathrop (1685-1754) and Deborah Crow (1694-1728) and died 20 August 1754 Bozrah, New London County, Connecticut, United States of unspecified causes. He married Elizabeth Bishop (1720-c1825) 10 February 1743 in Norwich, New London County, Connecticut, United States.
Children
| Name | Birth | Death | Joined with |
| Samuel Lathrop (1743-1801) | 30 November 1743 Norwich, New London County, Connecticut, United States | 14 June 1801 Wells, Rutland County, Vermont, United States | Sarah Oakman (1741-1825) |
| Thomas Lathrop (1745-1826) | 13 April 1745 Norwich, New London County, Connecticut, United States | 19 March 1826 Chittenden County, Vermont, United States | Welthy Ann Cobb (1753-1827) |
| Simon Lathrop (1747-1826) | 11 February 1747 Norwich, New London County, Connecticut, United States | 30 December 1826 Lisbon, New London County, Connecticut, United States | Esther Branch (1748-1830) |
Siblings
| Name | Birth | Death | Joined with |
| Deborah Lathrop (1716-1777) | 9 January 1717 | 14 October 1777 | Ephraim Avery (1713-1754) John Gardiner (1714-1764) Israel Putnam (1718-1790) |
| Ezra Lathrop (1718-1760) | |||
| Samuel Lathrop (1721-1754) | 1 January 1721 Norwich, New London County, Connecticut, United States | 20 August 1754 Bozrah, New London County, Connecticut, United States | Elizabeth Bishop (1720-c1825) |
| Elisha Lathrop (1723-1788) | |||
| Elizabeth Lathrop (1726-1726) | |||
| Hannah Lathrop (1728-1732) | |||